Common people travel by Daily Buses or Trains Which is very cheap and regular Trains/busses available from Alleppy to Cochin (1 h 2 min (53.0 km) via NH 66) and Cochin to Calicut ( 4 h 44 min (188.3 km) via NH 66) by train or bus. From Calicut to Wayanad (2 h 22 min (86.6 km) via NH766 ) by Bus or Car.  

Any travelers other than the group of a family above-mentioned way of traveling is the coast effective and best way to reach Wayanad. Distance between Alappuzha to Wayanad is 305 km by Road along with an aerial distance of 247 km.

There are no direct flights or trains or buses between Alappuzha to Wayanad.

From: Kochi, Kerala To: Wayanad, Kerala Time: 5 hours 33 mins Distance: 273.6 km

Kerala Govt Buses will charge very less orice compare to other private buses.

Best places to see on the way from Alappuzha to Wayanad are :
Cochin shipyard and Marine drive
Kodungallur Bhagavathy Temple
Thrissur Vadakkunnathan Temple
Bharathappuzha
Biyyam Kayal Ponnani
Feroke and old Bridge (Tipu Sultan's dream capital)
Canoli (Conolly) Canal Kozhikode Calicut.

Route by Train / Bus from Cochin (Ernakulam) to Wayanad :
Kochi > Thrissur > Shoranur > Tirur > Feroke > Calicut.

Shoranur to Kozhikode Trains (SRR to CLT), 54 trains (86kms)
The first train from Shoranur to Calicut is RAJDHANI EXP (12431) , which leaves around 00:50

Route by Road from Calicut to Wayanad :-
Calicut > Thamarassery > Adivaram (Ghat Road 14Kms) > Lakkidi >  Vythiri > Chundale > Kalpetta.
Thamarassery Churam is a mountain pass in Kerala,India across the Western Ghats. The highway has nine hairpin bends. Churam is about 14 kilometers in length, starting from Adivaram to Lakkidi View Point

Buses available from Calicut ( Kozhikode) KSRTC BUS STAND to different parts of Wayanad such as Kalpetta, Sulthan Bathery, Mananthavady, and Mysore.

Once you reach Calicut Railway station pick up Auto rickshaw  ( Tuk Tuk ) from the outside the Autoriksaw counter and reach to KSRTC Bus Stand. From there you will get many buses to Wayanad.